Diabetic Delayed Wound Healing and the Role of Silver Nanoparticles

Diabetes mellitus is most common disease of the altered glucose homeostasis. Diabetics have impaired wound healing and impaired formation of coronary collaterals. The abnormal apoptosis or angiogenesis may cause many of the clinical manifestations of diabetes. Silver has been known to have effective bactericidal properties for centuries. Nowadays, silver-based topical dressings have been widely used as a treatment for infections in burns, open wounds, and chronic ulcers. Silver nanoparticles are novel nanosized and highly crystalline antibacterial agent which carries Ag ions by ionexchanging. This review is an attempt to illustrate the molecular signaling of the apoptosis involved in delayed wound healing and the role of silver nanoparticles in earlier healing.